ENGLISH

Publications

業績

英文原著

(* corresponding author)

2024

Watanabe-Takano H, Kato K, Oguri-Nakamura E, Ishii T, Kobayashi K, Murata T, Tsujikawa K, Miyata T, Kubota Y, Hanada Y, Nishiyama K, Watabe T, Fässler R, Ishii H, Mochizuki N, Fukuhara S. Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts. Nat Commun. 2024 Mar 4;15(1):1622. doi: 10.1038/s41467-024-45910-y.

2023

Kiyotake Yamamoto, Haruko Watanabe-Takano, Eri Oguri-Nakamura, Hitomi Matsuno, Daiki Horikami, Tomohiro Ishii, Ryuji Ohashi, Yoshiaki Kubota, Koichi Nishiyama, Takahisa Murata, Naoki Mochizuki, Shigetomo Fukuhara, et al. Rap1 small GTPase is essential for maintaining pulmonary endothelial barrier function in mice. The FASEB J. 2023;37:e23310. doi:10.1096/fj.202300830RR

2022

Fujimoto K, Erickson S, Nakayama M, Ihara H, Sugihara K, Nashimoto Y, Nishiyama K, Miura T, Yokokawa R. Pericytes and shear stress each alter the shape of a self-assembled vascular network. Online ahead of print. Lab Chip.2022 Dec 20. doi: 10.1039/d2lc00605g.

Bu L, Yonemura A, Yasuda-Yoshihara N, Uchihara T, Ismagulov G, Takasugi S, Yasuda T, Okamoto Y, Kitamura F, Akiyama T, Arima K, Itoyama R, Zhang J, Fu L, Hu X, Wei F, Arima Y, Moroishi T,Nishiyama K, Sheng G, Mukunoki T, Otani J, Baba H, Ishimoto T. Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer. Cancer Sci. 2022 113(10):3579-3592. doi: 10.1111/cas.15495. Epub 2022 Aug 23.

Yuge S, Nishiyama K#*, Arima Y, Hanada Y, Oguri-Nakamura E, Hanada S, Ishii T, Wakayama Y, Hasegawa U, Tsujita K, Yokokawa R, Miura T, Itoh T, Tsujita K, Mochizuki N, Fukuhara S*. #These authors contributed equally to this work.  Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Nat Commun. 2022 May 12;13(1):2594. doi: 10.1038/s41467-022-30197-8.

2021

Muramatsu M, Ito T, Shimoji H, Komiya M, Miyamura Y, Nishiyama K, Suzuki T and Minami T. NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator. Biochem Biophys Res Commun 24;571:201-209, 2021. DOI: 10.1016/j.bbrc.2021.07.072

Yoshida N, Yamamoto S, Hamashima T, Okuno N, Okita N, Horikawa S, Hayashi M, Dang TC, Ngyuen QL, Nishiyama K, Makino T, Ishii Y, Tomihara K, Shimizu T, Shibuya M, Noguchi M and Sasahara M.  Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma. PNAS 118(19):e2019580118, 2021.DOI: 10.1073/pnas.2019580118

Arima Y, Nakagawa Y. Takeo T, Ishida T, Yamada T, Hino S, Nakao M, Hanada S, Umemoto T, Suda T, Sakuma T, Yamamoto T, Watanabe T, Nagaoka K, Tanaka Y. Kawamura YK, Tonami K, Kurihara H, Sato Y, Yamagata K, Nakamura T, Araki S, Yamamoto E, Izumiya Y, Sakamoto K, Kaikita K, Matsushita K, Nishiyama K, Nakagata N and Tsujita K.  Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation.  Nat Metab 3(2):196-210, 2021.DOI: 10.1038/s42255-021-00342-6

2020

Sugihara K, Yamaguchi Y, Usui S, Nashimoto Y, Hanada S, Kiyokawa E, Uemura A, Yokokawa R, Nishiyama K and Miura T. A new perfusion culture method with a self-organized capillary network. PLoS One 15(10):e0240552, 2020.doi.org/10.1371/journal. pone.0240552

Fukushima Y, Nishiyama K, Kataoka H, Fruttiger, M Fukuhara S, Nishida K, Mochizuki N, Kurihara H, Nishikawa S and Uemura A.  RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells. EMBO J 39(12);e102930, 2020. doi: 10.15252/embj.2019102930.

Nashimoto Y, Okada R, Hanada S, Arima Y, Nishiyama K, Miura T and Yokokawa R. Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid. Biomaterials 229:119547, 2020. doi: 10.1016/j.biomaterials.2020.119547.

2018

Nashimoto Y, Teraoka Y, Sadeghian RB, Nakamasu A, Arima Y, Hanada S, Kotera H, Nishiyama K, Miura T and Yokokawa R. Perfusable vascular Network with a tissue model in a microfluidic device. J Vis Exp 134:e57242, 2018.

Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y and Nakagawa O. Serum/glucocorticoid regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells. Angiogenesis 21(2):415-23, 2018. doi: 10.1007/s10456-018-9605-x.

Arima Y, Hokimoto S, Tabata N, Nakagawa O, Oshima A, Matsumoto Y, Sato T, Mukunoki T, Otani J, Ishii M, Uchikawa M, Yamamoto E, Izumiya Y, Kaikita K, Ogawa H, Nishiyama K and Tsujita K. Identification of the characteristic collateral source by three-dimensional analysis using micro X ray computed tomography. J Am Heart Assoc 7(6):3007800, 2018. doi: 10.1161/JAHA.117.007800.

2017

Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ. Study On The Tumor-Induced Angiogenesis Using Mathematical Models. Cancer Sci 109(1):15-23, 2017. doi: 10.1111/cas.13395.

Nashimoto Y, Hayashi T, Kunita I, Nakamasu A, Torisawa YS, Nakayama M, Takigawa-Imamura H, Kotera H, Nishiyama K, Miura T, and Yokokawa R.Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device. Integr Biol (Camb) 9(6):506-518, 2017. doi: 10.1039/c7ib00024c.

2015

Sugihara K#, Nishiyama K#*, Fukuhara S, Uemura A, Arima S, Kobayashi R, Köhn-Luque A, Mochizuki N, Suda T, Ogawa H, and Kurihara H. #These authors contributed equally to this work. Autonomy and non-autonomy of angiogenic cell movements revealed by experiment-driven mathematical modeling. Cell Rep, 13(9):1814-27, 2015. http://dx.doi.org/10.1016/j.celrep.2015.10.051.

Sueta D, Yamamoto E, Tanaka T, Hirata Y, Sakamoto K, Tsujita K, Kojima S, Nishiyama K, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H. The accuracy of central blood pressure waveform by novel mathematical transformation of non-invasive measurement. Int J Cardiol 189:244-61, 2015. DOI: 10.1016/j.ijcard.2015.03.182.

2014

Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kuriara H., Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, and Komuro I. Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart. Nat Commun 5:4452, 2014. DOI: 10.1016/j.ijcard.2015.03.182

2013

Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, & Kurihara H. Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms. Mech Dev 130(11-12):553-66, 2013. DOI: 10.1016/j.mod.2013.07.005

Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T. Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development. Arterioscler Thromb Vasc Biol 33(8):1986-92, 2013. DOI: 10.1161/ATVBAHA.113.301546

2012

Arima Y, Miyagawa-Tomita S, Maeda K, Asai R, Seya D, Minoux M, Rijli FM, Nishiyama K, Kim KS, Uchijima Y, Ogawa H, Kurihara Y, Kurihara H. Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling. Nat Commun 3:1267, 2012. DOI: 10.1038/ncomms2258

2011

Arima S#, Nishiyama K#*, Ko T, Arima Y, Hakozaki Y, Sugihara K, Koseki H, Uchijima Y, Kurihara Y, Kurihara H. #These authors contributed equally to this work. Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement. Development 138(21):4763-76, 2011. DOI: 10.1242/dev.06802

Kitazawa T, Sato T, Nishiyama K, Asai R., Arima Y, Uchijima Y, Kurihara Y, Kurihara H. Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney. Gene Exp Pattern 11(7):371-7, 2011. DOI: 10.1016/j.gep.2011.04.001

Tonami K, Kurihara Y, Arima S, Nishiyama K, Uchijima Y, Asano T, Sorimachi H, Kurihara H. Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1. J Cell Sci 124:1214-23, 2011. DOI: 10.1242/jcs.072561

2010

Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M. Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood 115(20):4138-44, 2010. DOI: 10.1182/blood-2009-05-223057

Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H. Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation. Development 518(23):4702-22, 2010. DOI: 10.1242/dev.054015

Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J. Clin Invest 120(8): 2817-28, 2010. DOI: 10.1172/JCI42020

Fujimoto C, Ozeki H, Uchijima Y, Suzukawa K, Mitani A, Fukuhara S, Nishiyama K, Kurihara Y, Kondo K, Aburatani H, Kaga K, Yamasoba T, Kurihara H. Establishment of mice expressing EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst. J. Comp Neurol 518(23): 4702-22, 2010. DOI: 10.1002/cne.22468

2008

Horike N, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Kamata H, Nishiyama K, Uchijima Y, Kurihara Y, Kurihara H, Asano T.AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J Biol Chem 283(49): 33902-10, 2008. DOI: 10.1074/jbc.M802537200

Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Small EV, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol 294(3):F542-53, 2008. DOI: 10.1152/ajprenal.00201.2007

2007

Nishiyama K.* , Takaji K., Uchijima Y., Kurihara Y., Asano T., Yoshimura M., Ogawa H., Kurihara H. Protein kinase A-regulated nucleocytoplasmic shuttling of Id1 during angiogenesis. J Biol Chem 282(23):17200-9, 2007.
DOI: 10.1074/jbc.M611609200

2005

Nishiyama K*, Takaji K, Kataoka K, Kurihara Y, Yoshimura M, Kato K, Ogawa H, Kurihara H. Id1 Gene Transfer Confers Angiogenic Property on Fully Differentiated Endothelial Cells and Contributes to Therapeutic Angiogenesis.
Circulation 112:2840-2850, 2005.
DOI: 10.1161/CIRCULATIONAHA.104.516898

Kushiyama A, Shojima N, Ogihara T, Inukai K, Sakoda H, Fujishiro M, Fukushima Y, Anai M, Ono H, Horike N, Viana AY, Uchijima Y, Nishiyama K, Shimosawa T, Fujita T, Katagiri H, Oka Y., Kurihara H, Asano T. Resistin like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes and induces diabetes, hyperlipidemia and fatty liver in transgenic mice on a high-fat diet. J Biol Chem 280(51):42016-25, 2005.
DOI: 10.1074/jbc.M503065200

2001

Nishiyama K, Yasue H, Moriyama Y, Tsunoda R, Ogawa H, Yoshimura M, Kugiyama K. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men. Am Heart J 141(5):E9, 2001.

2000

Ogawa H, Suefuji H, Soejima H, Nishiyama K, Misumi K, Takazoe K, Miyamoto S, Kajiwara I, Sumida H, Sakamoto T, Yoshimura M, Kugiyama K, Yasue H, Matsuo K. Increased blood vascular endothelial growth factor levels in patients with acute myocardial infarction. Cardiology 93(1-2):93-9, 2000. DOI: 10.1159/000007008

Moriyama Y, Yasue H, Yoshimura M, Mizuno Y, Nishiyama K, Tsunoda R, Kawano H, Kugiyama K, Ogawa H, Saito Y, Nakao K. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrinol Metab 85(5):1834-40, 2000. DOI: 10.1210/jc.85.5.1834

Ogawa H, Sakamoto T, Nishiyama K, Soejima H, Kaikita K, Takazoe K, Miyamoto S, Kugiyama K, Yoshimura M, Yasue H. Elevated levels of soluble intercellular adhesion molecule-1 in the coronary circulation of patients with coronary organic stenosis and spasm. Jpn Circ J 64(3):170-6, 2000. DOI: 10.1253/jcj.64.170

1999

Soejima H, Ogawa H, Yasue H, Kaikita K, Takazoe K, Nishiyama K, Misumi K, Miyamoto S, Yoshimura M, Kugiyama K, Nakamura S, Tsuji I. Angiotensin-converting enzyme inhibition reduces monocyte chemoattractant protein-1 and tissue factor levels in patients with myocardial infarction. J Am Coll Cardiol 34(4):983-8, 1999. DOI: 10.1016/S0735-1097(99)00318-6

Soejima H, Ogawa H, Yasue H, Kaikita K, Nishiyama K, Misumi K, Takazoe K, Miyao Y, Yoshimura M, Kugiyama K, Nakamura S, Tsuji I, Kumeda K. Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis in patients with unstable angina. Circulation 99(22):2908-13, 1999.

Ogawa H, Yasue H, Miyao Y, Sakamoto T, Soejima H, Nishiyama K, Kaikita K, Suefuji H, Misumi K, Takazoe K, Kugiyama K, Yoshimura M. Plasma soluble intercellular adhesion molecule-1 levels in coronary circulation in patients with unstable angina. Am J Cardiol 83(1):38-42, 1999.
DOI: 10.1016/S0002-9149(98)00779-6

Soejima H, Ogawa H, Yasue H, Nishiyama K, Kaikita K, Misumi K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K, Nakamura S. Plasma tissue factor pathway inhibitor and tissue factor antigen levels after administration of heparin in patients with angina pectoris. Thromb Res 93(1):17-25, 1999. DOI: 10.1016/S0049-3848(98)00147-9

1998

Moriyama Y, Ogawa H, Oshima S, Arai H, Takazoe K, Shimomura H, Hirai N, Suefuji H, Soejima H, Nishiyama K, Misumi K, Yasue H. Relationship between serum angiotensin-converting enzyme activity and plasma plasminogen activator inhibitor activity in patients with recent myocardial infarction. Coron Artery Dis 9(10):691-6, 1998.
Nishiyama K, Ogawa H, Yasue H, Soejima H, Misumi K, Takazoe K, Yoshimura M, Kugiyama K, Tsuji I, Kumeda K. Simultaneous elevation of the levels of circulating monocyte chemoattractant protein-1 and tissue factor in acute coronary syndromes. Jpn Circ J 62(9):710-2, 1998. DOI: 10.1253/jcj.62.710

Misumi K, Ogawa H, Yasue H, Soejima H, Suefuji H, Nishiyama K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K. Circadian variation in plasma levels of free-form tissue factor pathway inhibitor antigen in patients with coronary spastic angina. Jpn Circ J 62(6):419-24, 1998. DOI: 10.1253/jcj.62.419

Nishiyama K, Ogawa H, Yasue H, Soejima H, Misumi K, Kugiyama K, Tsuji I, Kumeda K. Heparin-releasable endothelial cell-associated tissue factor pathway inhibitor (TFPI) is increased in the coronary circulation after coronary spasm in patients with coronary spastic angina. Thromb Res 89(3):137-46, 1998. DOI: 10.1016/S0049-3848(97)00309-5

Shimomura H., Ogawa H., Arai H., Moriyama Y., Takazoe K., Hirai N., Kaikita K., Hirashima O., Misumi K., Soejima H., Nishiyama K., Yasue H. Serial changes in plasma levels of soluble P-selectin in patients with acute myocardial infarction. Am J Cardiol 81(4):397-400, 1998. DOI: 10.1016/S0002-9149(97)00945-4

Misumi K, Ogawa H, Yasue H, Soejima H, Suefuji H, Nishiyama K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K, Nakamura S. Comparison of plasma tissue factor levels in unstable and stable angina pectoris. Am J Cardiol 81(1):22-6, 1998. DOI: 10.1016/S0002-9149(97)00801-1

1997

Soejima H, Ogawa H, Yasue H, Suefuji H, Kaikita K, Nishiyama K. Effects of imidapril therapy on endogenous fibrinolysis in patients with recent myocardial infarction. Clin Cardiol 20(5):441-5, 1997.

1996

Suefuji H, Ogawa H, Yasue H, Imoto N, Sakamoto T, Miyao Y, Kaikita K, Soejima H, Nishiyama K. Effect of niceritrol on fibrinolysis and lipoprotein (a) levels in patients with coronary artery disease. Coron Artery Dis 7(2), 167-72 (1996). DOI: 10.1097/00019501-199602000-00012

1995

Saito T, Yashita S, Noda K, Mizuno Y, Kawabata S, Higa T, Nakahashi E, Iwasa A, Nishiyama K, Ohshima S. Clinical experience with the ACS RX Lifestream coronary dilatation catheter: a new low profile perfusion balloon catheter. J Invasive Cardiol 7 Suppl B:39B-45B, discussion 50B-56B, 1995.

日本語総説、書籍等

西山功一 血管新生研究up-to-date -血流による血管新生の力学的制御メカニズムと医療応用の可能性 宮崎医会誌 46:128-135,2022

西山功一 In vitro再構成モデルを用いた血管新生における血流力学作用の解析 生体の科学 73(6):1─6,2022

西山功一 花田保之 血管・リンパ管の機能制御と疾患メカニズム 化学同人 14: 129-140, 2022

西山功一 生体分子イメージングによる微小環境の可視化と病態解析 日本冠疾患学会雑誌 24: 1-7, 2018

西山功一 発見から100年、ベールを脱ぐペリサイト 実験医学 36(1): 87-93, 2018

西山功一 血管作りに秘められた細胞集団の挙動 細胞工学 33(6): 639-643, 2014

栗原裕基、有馬聡、西山功一 血管新生の細胞動態解析 生体の科学 65(5):428-429, 2014

西山功一 in vitroライブイメージングと定量解析による血管新生機構の解明 日本血栓止血学会誌  24(6): 553-559, 2013

西山功一 「Id」血管生物医学事典 375-77, 2011

西山功一 「NO, NOS」血管生物医学事典 95-7, 2011

藤沢興、西山功一「エンドセリン」血管生物医学事典112-3, 2011

西山功一、有馬聡、栗原裕基.「In vitro ライブイメージングによる血管新生機構の解明.」 血管医学 11(3):77-84, 2010

西山功一、 栗原 裕基 各分野におけるノーベル賞の貢献 循環器疾患. 総合臨床 57(1):54-60, 2008

西山功一 血管の生理と病態モデル 虚血. 血管医学 8(2):79-86, 2007

西山功一 血管内皮前駆細胞 循環器科 60(5):449-456, 2006

西山功一、栗原裕基 血管新生と内皮前駆細胞:血管内皮細胞をめぐる疾患(島田和幸編) 29-42, 2006