Publications
2022
Fujimoto K, Erickson S, Nakayama M, Ihara H, Sugihara K, Nashimoto Y, Nishiyama K, Miura T, Yokokawa R. Pericytes and shear stress each alter the shape of a self-assembled vascular network. Online ahead of print. Lab Chip.2022 Dec 20. doi: 10.1039/d2lc00605g.
Bu L, Yonemura A, Yasuda-Yoshihara N, Uchihara T, Ismagulov G, Takasugi S, Yasuda T, Okamoto Y, Kitamura F, Akiyama T, Arima K, Itoyama R, Zhang J, Fu L, Hu X, Wei F, Arima Y, Moroishi T,Nishiyama K, Sheng G, Mukunoki T, Otani J, Baba H, Ishimoto T. Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer. Cancer Sci. 2022 113(10):3579-3592. doi: 10.1111/cas.15495. Epub 2022 Aug 23.
Yuge S, Nishiyama K#*, Arima Y, Hanada Y, Oguri-Nakamura E, Hanada S, Ishii T, Wakayama Y, Hasegawa U, Tsujita K, Yokokawa R, Miura T, Itoh T, Tsujita K, Mochizuki N, Fukuhara S*. #These authors contributed equally to this work. Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. Nat Commun. 2022 May 12;13(1):2594. doi: 10.1038/s41467-022-30197-8.
2021
Muramatsu M, Ito T, Shimoji H, Komiya M, Miyamura Y, Nishiyama K, Suzuki T and Minami T. NFAT indicates nucleocytoplasmic damped oscillation via its feedback modulator. Biochem Biophys Res Commun 24;571:201-209, 2021. DOI: 10.1016/j.bbrc.2021.07.072
Yoshida N, Yamamoto S, Hamashima T, Okuno N, Okita N, Horikawa S, Hayashi M, Dang TC, Ngyuen QL, Nishiyama K, Makino T, Ishii Y, Tomihara K, Shimizu T, Shibuya M, Noguchi M and Sasahara M. Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma. PNAS 118(19):e2019580118, 2021.DOI: 10.1073/pnas.2019580118
Arima Y, Nakagawa Y. Takeo T, Ishida T, Yamada T, Hino S, Nakao M, Hanada S, Umemoto T, Suda T, Sakuma T, Yamamoto T, Watanabe T, Nagaoka K, Tanaka Y. Kawamura YK, Tonami K, Kurihara H, Sato Y, Yamagata K, Nakamura T, Araki S, Yamamoto E, Izumiya Y, Sakamoto K, Kaikita K, Matsushita K, Nishiyama K, Nakagata N and Tsujita K. Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation. Nat Metab 3(2):196-210, 2021.DOI: 10.1038/s42255-021-00342-6
2020
Sugihara K, Yamaguchi Y, Usui S, Nashimoto Y, Hanada S, Kiyokawa E, Uemura A, Yokokawa R, Nishiyama K and Miura T. A new perfusion culture method with a self-organized capillary network. PLoS One 15(10):e0240552, 2020.doi.org/10.1371/journal. pone.0240552
Fukushima Y, Nishiyama K#*, Kataoka H, Fruttiger, M Fukuhara S, Nishida K, Mochizuki N, Kurihara H, Nishikawa S and Uemura A. RhoJ integrates attractive and repulsive cues in directional migration of endothelial cells. EMBO J 39(12);e102930, 2020. doi: 10.15252/embj.2019102930.
Nashimoto Y, Okada R, Hanada S, Arima Y, Nishiyama K, Miura T and Yokokawa R. Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid. Biomaterials 229:119547, 2020. doi: 10.1016/j.biomaterials.2020.119547.
2018
Nashimoto Y, Teraoka Y, Sadeghian RB, Nakamasu A, Arima Y, Hanada S, Kotera H, Nishiyama K, Miura T and Yokokawa R. Perfusable vascular Network with a tissue model in a microfluidic device. J Vis Exp 134:e57242, 2018.
Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y and Nakagawa O. Serum/glucocorticoid regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells. Angiogenesis 21(2):415-23, 2018. doi: 10.1007/s10456-018-9605-x.
Arima Y, Hokimoto S, Tabata N, Nakagawa O, Oshima A, Matsumoto Y, Sato T, Mukunoki T, Otani J, Ishii M, Uchikawa M, Yamamoto E, Izumiya Y, Kaikita K, Ogawa H, Nishiyama K and Tsujita K. Identification of the characteristic collateral source by three-dimensional analysis using micro X ray computed tomography. J Am Heart Assoc 7(6):3007800, 2018. doi: 10.1161/JAHA.117.007800.
2017
Suzuki T, Minerva D, Nishiyama K, Koshikawa N, Chaplain MAJ. Study On The Tumor-Induced Angiogenesis Using Mathematical Models. Cancer Sci 109(1):15-23, 2017. doi: 10.1111/cas.13395.
Nashimoto Y, Hayashi T, Kunita I, Nakamasu A, Torisawa YS, Nakayama M, Takigawa-Imamura H, Kotera H, Nishiyama K, Miura T, and Yokokawa R.Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device. Integr Biol (Camb) 9(6):506-518, 2017. doi: 10.1039/c7ib00024c.
2015
Sugihara K#, Nishiyama K#*, Fukuhara S, Uemura A, Arima S, Kobayashi R, Köhn-Luque A, Mochizuki N, Suda T, Ogawa H, and Kurihara H. #These authors contributed equally to this work. Autonomy and non-autonomy of angiogenic cell movements revealed by experiment-driven mathematical modeling. Cell Rep, 13(9):1814-27, 2015. http://dx.doi.org/10.1016/j.celrep.2015.10.051.
Sueta D, Yamamoto E, Tanaka T, Hirata Y, Sakamoto K, Tsujita K, Kojima S, Nishiyama K, Kaikita K, Hokimoto S, Jinnouchi H, Ogawa H. The accuracy of central blood pressure waveform by novel mathematical transformation of non-invasive measurement. Int J Cardiol 189:244-61, 2015. DOI: 10.1016/j.ijcard.2015.03.182.
2014
Arita Y, Nakaoka Y, Matsunaga T, Kidoya H, Yamamizu K, Arima Y, Kataoka-Hashimoto T, Ikeoka K, Yasui T, Masaki T, Yamamoto K, Higuchi K, Park JS, Shirai M, Nishiyama K, Yamagishi H, Otsu K, Kuriara H., Minami T, Yamauchi-Takihara K, Koh GY, Mochizuki N, Takakura N, Sakata Y, Yamashita JK, and Komuro I. Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart. Nat Commun 5:4452, 2014. DOI: 10.1016/j.ijcard.2015.03.182
2013
Kim KS, Arima Y, Kitazawa T, Nishiyama K, Asai R, Uchijima Y, Sato T, Levi G, Kitanaka S, Igarashi T, Kurihara Y, & Kurihara H. Endothelin regulates neural crest deployment and fate to form great vessels through Dlx5/Dlx6-independent mechanisms. Mech Dev 130(11-12):553-66, 2013. DOI: 10.1016/j.mod.2013.07.005
Fukushima T, Kamata H, Nishimura F, Kikuchi T, Fujishiro M, Nishiyama K, Aburatani H, Kushiyama S, Iizuka M, Taki N, Encinas J, Sentani K, Ogonuki N, Ogura A, Kawazu S, Yasui W, Higashi Y, Kurihara H, Katagiri H, Asano T. Resistin-like molecule β is abundantly expressed in foam cells and is involved in atherosclerosis development. Arterioscler Thromb Vasc Biol 33(8):1986-92, 2013. DOI: 10.1161/ATVBAHA.113.301546
2012
Arima Y, Miyagawa-Tomita S, Maeda K, Asai R, Seya D, Minoux M, Rijli FM, Nishiyama K, Kim KS, Uchijima Y, Ogawa H, Kurihara Y, Kurihara H. Preotic neural crest cells contribute to coronary artery smooth muscle involving endothelin signalling. Nat Commun 3:1267, 2012. DOI: 10.1038/ncomms2258
2011
Arima S#, Nishiyama K#*, Ko T, Arima Y, Hakozaki Y, Sugihara K, Koseki H, Uchijima Y, Kurihara Y, Kurihara H. #These authors contributed equally to this work. Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement. Development 138(21):4763-76, 2011. DOI: 10.1242/dev.06802
Kitazawa T, Sato T, Nishiyama K, Asai R., Arima Y, Uchijima Y, Kurihara Y, Kurihara H. Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney. Gene Exp Pattern 11(7):371-7, 2011. DOI: 10.1016/j.gep.2011.04.001
Tonami K, Kurihara Y, Arima S, Nishiyama K, Uchijima Y, Asano T, Sorimachi H, Kurihara H. Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1. J Cell Sci 124:1214-23, 2011. DOI: 10.1242/jcs.072561
2010
Tanaka A, Itoh F, Nishiyama K, Takezawa T, Kurihara H, Itoh S, Kato M. Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis. Blood 115(20):4138-44, 2010. DOI: 10.1182/blood-2009-05-223057
Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H. Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation. Development 518(23):4702-22, 2010. DOI: 10.1242/dev.054015
Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H. Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J. Clin Invest 120(8): 2817-28, 2010. DOI: 10.1172/JCI42020
Fujimoto C, Ozeki H, Uchijima Y, Suzukawa K, Mitani A, Fukuhara S, Nishiyama K, Kurihara Y, Kondo K, Aburatani H, Kaga K, Yamasoba T, Kurihara H. Establishment of mice expressing EGFP in the placode-derived inner ear sensory cell lineage and FACS-array analysis focused on the regional specificity of the otocyst. J. Comp Neurol 518(23): 4702-22, 2010. DOI: 10.1002/cne.22468
2008
Horike N, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Kamata H, Nishiyama K, Uchijima Y, Kurihara Y, Kurihara H, Asano T.AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J Biol Chem 283(49): 33902-10, 2008. DOI: 10.1074/jbc.M802537200
Makita R, Uchijima Y, Nishiyama K, Amano T, Chen Q, Takeuchi T, Mitani A, Nagase T, Yatomi Y, Aburatani H, Nakagawa O, Small EV, Cobo-Stark P, Igarashi P, Murakami M, Tominaga J, Sato T, Asano T, Kurihara Y, Kurihara H. Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol 294(3):F542-53, 2008. DOI: 10.1152/ajprenal.00201.2007
2007
Nishiyama K.* , Takaji K., Uchijima Y., Kurihara Y., Asano T., Yoshimura M., Ogawa H., Kurihara H. Protein kinase A-regulated nucleocytoplasmic shuttling of Id1 during angiogenesis. J Biol Chem 282(23):17200-9, 2007.
DOI: 10.1074/jbc.M611609200
2005
Nishiyama K*, Takaji K, Kataoka K, Kurihara Y, Yoshimura M, Kato K, Ogawa H, Kurihara H. Id1 Gene Transfer Confers Angiogenic Property on Fully Differentiated Endothelial Cells and Contributes to Therapeutic Angiogenesis.
Circulation 112:2840-2850, 2005.
DOI: 10.1161/CIRCULATIONAHA.104.516898
Kushiyama A, Shojima N, Ogihara T, Inukai K, Sakoda H, Fujishiro M, Fukushima Y, Anai M, Ono H, Horike N, Viana AY, Uchijima Y, Nishiyama K, Shimosawa T, Fujita T, Katagiri H, Oka Y., Kurihara H, Asano T. Resistin like molecule beta activates MAPKs, suppresses insulin signaling in hepatocytes and induces diabetes, hyperlipidemia and fatty liver in transgenic mice on a high-fat diet. J Biol Chem 280(51):42016-25, 2005.
DOI: 10.1074/jbc.M503065200
2001
Nishiyama K, Yasue H, Moriyama Y, Tsunoda R, Ogawa H, Yoshimura M, Kugiyama K. Acute effects of melatonin administration on cardiovascular autonomic regulation in healthy men. Am Heart J 141(5):E9, 2001.
2000
Ogawa H, Suefuji H, Soejima H, Nishiyama K, Misumi K, Takazoe K, Miyamoto S, Kajiwara I, Sumida H, Sakamoto T, Yoshimura M, Kugiyama K, Yasue H, Matsuo K. Increased blood vascular endothelial growth factor levels in patients with acute myocardial infarction. Cardiology 93(1-2):93-9, 2000. DOI: 10.1159/000007008
Moriyama Y, Yasue H, Yoshimura M, Mizuno Y, Nishiyama K, Tsunoda R, Kawano H, Kugiyama K, Ogawa H, Saito Y, Nakao K. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrinol Metab 85(5):1834-40, 2000. DOI: 10.1210/jc.85.5.1834
Ogawa H, Sakamoto T, Nishiyama K, Soejima H, Kaikita K, Takazoe K, Miyamoto S, Kugiyama K, Yoshimura M, Yasue H. Elevated levels of soluble intercellular adhesion molecule-1 in the coronary circulation of patients with coronary organic stenosis and spasm. Jpn Circ J 64(3):170-6, 2000. DOI: 10.1253/jcj.64.170
1999
Soejima H, Ogawa H, Yasue H, Kaikita K, Takazoe K, Nishiyama K, Misumi K, Miyamoto S, Yoshimura M, Kugiyama K, Nakamura S, Tsuji I. Angiotensin-converting enzyme inhibition reduces monocyte chemoattractant protein-1 and tissue factor levels in patients with myocardial infarction. J Am Coll Cardiol 34(4):983-8, 1999. DOI: 10.1016/S0735-1097(99)00318-6
Soejima H, Ogawa H, Yasue H, Kaikita K, Nishiyama K, Misumi K, Takazoe K, Miyao Y, Yoshimura M, Kugiyama K, Nakamura S, Tsuji I, Kumeda K. Heightened tissue factor associated with tissue factor pathway inhibitor and prognosis in patients with unstable angina. Circulation 99(22):2908-13, 1999.
Ogawa H, Yasue H, Miyao Y, Sakamoto T, Soejima H, Nishiyama K, Kaikita K, Suefuji H, Misumi K, Takazoe K, Kugiyama K, Yoshimura M. Plasma soluble intercellular adhesion molecule-1 levels in coronary circulation in patients with unstable angina. Am J Cardiol 83(1):38-42, 1999.
DOI: 10.1016/S0002-9149(98)00779-6
Soejima H, Ogawa H, Yasue H, Nishiyama K, Kaikita K, Misumi K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K, Nakamura S. Plasma tissue factor pathway inhibitor and tissue factor antigen levels after administration of heparin in patients with angina pectoris. Thromb Res 93(1):17-25, 1999. DOI: 10.1016/S0049-3848(98)00147-9
1998
Moriyama Y, Ogawa H, Oshima S, Arai H, Takazoe K, Shimomura H, Hirai N, Suefuji H, Soejima H, Nishiyama K, Misumi K, Yasue H. Relationship between serum angiotensin-converting enzyme activity and plasma plasminogen activator inhibitor activity in patients with recent myocardial infarction. Coron Artery Dis 9(10):691-6, 1998.
Nishiyama K, Ogawa H, Yasue H, Soejima H, Misumi K, Takazoe K, Yoshimura M, Kugiyama K, Tsuji I, Kumeda K. Simultaneous elevation of the levels of circulating monocyte chemoattractant protein-1 and tissue factor in acute coronary syndromes. Jpn Circ J 62(9):710-2, 1998. DOI: 10.1253/jcj.62.710
Misumi K, Ogawa H, Yasue H, Soejima H, Suefuji H, Nishiyama K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K. Circadian variation in plasma levels of free-form tissue factor pathway inhibitor antigen in patients with coronary spastic angina. Jpn Circ J 62(6):419-24, 1998. DOI: 10.1253/jcj.62.419
Nishiyama K, Ogawa H, Yasue H, Soejima H, Misumi K, Kugiyama K, Tsuji I, Kumeda K. Heparin-releasable endothelial cell-associated tissue factor pathway inhibitor (TFPI) is increased in the coronary circulation after coronary spasm in patients with coronary spastic angina. Thromb Res 89(3):137-46, 1998. DOI: 10.1016/S0049-3848(97)00309-5
Shimomura H., Ogawa H., Arai H., Moriyama Y., Takazoe K., Hirai N., Kaikita K., Hirashima O., Misumi K., Soejima H., Nishiyama K., Yasue H. Serial changes in plasma levels of soluble P-selectin in patients with acute myocardial infarction. Am J Cardiol 81(4):397-400, 1998. DOI: 10.1016/S0002-9149(97)00945-4
Misumi K, Ogawa H, Yasue H, Soejima H, Suefuji H, Nishiyama K, Takazoe K, Kugiyama K, Tsuji I, Kumeda K, Nakamura S. Comparison of plasma tissue factor levels in unstable and stable angina pectoris. Am J Cardiol 81(1):22-6, 1998. DOI: 10.1016/S0002-9149(97)00801-1
1997
Soejima H, Ogawa H, Yasue H, Suefuji H, Kaikita K, Nishiyama K. Effects of imidapril therapy on endogenous fibrinolysis in patients with recent myocardial infarction. Clin Cardiol 20(5):441-5, 1997.
1996
Suefuji H, Ogawa H, Yasue H, Imoto N, Sakamoto T, Miyao Y, Kaikita K, Soejima H, Nishiyama K. Effect of niceritrol on fibrinolysis and lipoprotein (a) levels in patients with coronary artery disease. Coron Artery Dis 7(2), 167-72 (1996). DOI: 10.1097/00019501-199602000-00012
1995
Saito T, Yashita S, Noda K, Mizuno Y, Kawabata S, Higa T, Nakahashi E, Iwasa A, Nishiyama K, Ohshima S. Clinical experience with the ACS RX Lifestream coronary dilatation catheter: a new low profile perfusion balloon catheter. J Invasive Cardiol 7 Suppl B:39B-45B, discussion 50B-56B, 1995.
